Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1168 | Nuclear receptors and Signal transduction | ICEECE2012

PPARγ activator may improve sepsis symptom by inhibiting inflammation in adipose tissue

Kutsukake M. , Kobayashi M. , Tamura K. , Yoshie M. , Tachikawa E. , Matsuda A. , Uchida E. , Matsutani T.

Introduction: Postoperative sepsis exhibits high mortality. Prevention of postoperative infection and palliation of sepsis symptom are important issues in the patient’s care after surgical operation. Adipose tissue as an endocrine organ that secretes various cytokines. Circulating adiponectin, an anti-inflammatory cytokine, and inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α are derived partially from adipose tissues. Recent studie...

ea0029oc5.4 | Obesity Basic | ICEECE2012

Bile acid binding resin shows anti-obese effect through the modifications of intestinal microbiota

Kusumoto Y. , Irie J. , Tagawa H. , Itoh A. , Kato M. , Kobayashi N. , Tanaka K. , Yamada S. , Kawai T. , Itoh H.

The growing epidemic of obesity has led health professionals to understand the pathophysiology of obesity and its complications. Gut microbiota are of special interest, since some kinds of microbiota such as Bacteroides are less in obese persons and some microbiota induce obesity in animals by effective fat storage through microbiota-mediated intestinal Fiaf (Fasting-induced adipose factor) suppressions. Recently, bile acid-binding resins (BARs), non-absorbable drug for dyslip...